My biggest worries are that the character systems are:
- onesided (every skill exists to engage in or avoid combat),
- unvaried (there are no utility skills for less common activities -- i.e. no skill for driving, social interactions, or other 2020 things like forgery, languages, human perception, geology, etc),
- unimpactful (they do very little difference in how the game plays and how the character works),
- predictable (just a basic set seen in hundreds of other games, doing exactly the same things with no surprises),
- gimmicky in places -- I fear the one lifepath choice we have is left as a gimmick that bears no significance anywhere but in the intro and few choice lines in scripted sequences, that that single choice for lifepath we have is overglorified and the affect to the intro sequence just won't cover as much ground as a few lesser, but differing choices could.
and that the world interaction (through said systems) is nothing short of non-existent; that there's very very little to engage in between missions.
I fear that gun combat, inspite of what is said about how the stats are supposed to affect it, is too much like a straightforward FPS (because the developer might be afraid to make the governing systems as impactful as the should be for them to feel like they make a difference, because it would be clumsy early on); and that the smart gun systems won't be helping with that (autohitting with curving bullets is just not a substitute for unimpactful stats).
And I fear that the storytelling focus dictates too much of how the game plays and how we can express our character (immortal companions that are in the way and are not helpful, unkillable NPC's which leads to less choice and consequence, ridig structure to follow even if individual missions might have choices and options in them (i.e. what they said about having to visit ripperdocs to progress), distractingly obvious levelscaling design).
All that combined, I fear the game gets boring, repetitive and colourless to play in the long run. Just like Witcher 3 did.
That's about it. Mostly gameplay related things.
Core storytelling and mission design will probably be good, audiodesign will probably be good, visual design is already better than needed. Bugs and glitches don't bother me, unless they break the game. The game isn't going to be too short for certain.
So what I fear is that the jelly doughnut that's being advertised might not have jelly and has half it's sugar replaced with salt. It looks the part, but...will it also walk the walk.