I'm pretty sure this is exactly what they've been aiming for since the beginning though. Like with the Samurai jacket for example. There's been plenty of times where they've said it will have a direct affect on how you interact with characters and how they treat you. Like wearing an animals muscle shirt in Pacifica could probably get you jumped.If you mean that they react by a throwaway voice line, then yeah. "Hey dude, cool car!"
I was thinking more like muggers leaving the PC alone or treating him with respect if you are a famous mercenary known for combat prowess etc.... but I doubt that will actually happen.
Even Silverhand reacts to your clothing and such.
We'll see though.