I did play Night's Edge. We played Vampires and got in a tangle with a Pharmaceutical company that also had Vampires. And the wrinkle was, there was a third faction of Lycanthropes (werewolves) who were against both of the Vampire factions - kind of a "fatal three-way". Ultimately, the experiment was unsuccessful... technology really has a way of levelling the playing field as far as human-vampire-werewolf situation goes. I think the setting could have been better done with much more thought and a lot of "further development". Certainly Vampires and Werewolves would have their own technologies and research to counter the tech humans can come up with. But as it is presented, I think it needs more work.
I will say that Night's Edge and its other sourcebooks have some really interesting rules regarding psychosis, consequences of addiction, street drugs and a few other things that add a lot to a normal CP2020 campaign.