10. Set the "Witcher3.exe" process to "High Priority" in Task Manager to win some extra frames-per-second
It would appear that The Witcher 3: Wild Hunt is not making effective use of CPU power and that setting the "Witcher3.exe" process to "High Affinity" in Task Manager can help alleviate this problem and win you some extra frames-per-second!
With the game running, Alt-Tab back to the desktop and then press Ctrl-Alt-Del to bring up Task Manager. Find the "Witcher3.exe" process, right-click on it then select "Set Priority > High". After that, you can simply close Task Manager and Alt-Tab back into the game!
Source: TheRaidenPT
Alternatively, if you want the game to always run at a high priority, then open Notepad and copy/paste the following in a new .txt file:
Windows Registry Editor Version 5.00
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\Image File Execution Options\witcher3.exe]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\Image File Execution Options\witcher3.exe\PerfOptions]
"CpuPriorityClass"=dword:00000003
Then save the file with the extension .reg (e.g. "witcher_priority.reg") wherever you want, double-click on it and select "Ok" to add the new key to your registry!
Source: Black_Iris