The post on meditating was good, but not complete. Try this: take the long pots, the one that doubles life, the one that doubles endurance, and the one that give greater chance for crit hit. Then meditate for 2 hours to clear all toxicity. Then take swallow, the enduranc rejuvinator, and the 2 that stop bleeding and stun. This assumes that you have put points into reducing toxitcity. I did this and killed both the Koch and Javed in one run on normal diff. Also use argentia on silver, and diamond dust on the steel sword.