Not for me. TW3 has no choice/consequence system. Not for the decisions which were taken in the previous games or those which are taken in TW3. Almost every aspect of the game seems adapted for a child of 12 years. And, speaking about the sales. We, (the fans of the previous games) also made an excellent job praising W2 and W1 and sayint that they were the best RPG games with the best narrative for adults. Real tough and grey decisions. And I think that a significant part of us wouldn't had done this if we would had known which was going to be the result. Without that, I think TW3 wouldn't had sold so well. Now, I prefer ME saga or even DA Origins. I want to se what happens with Cyberpunk
TW3 is so huge that I can't blame authors that they didn't create really diverse and consecutive ways to walkthrough it. At PS4 achievements I see that only 50% of players ever completed the game and only 5% made it on hard difficulty (i.e. played second time). And there is only one class, one gender, all relationships are available during one playthrough and with clarity potion you can try any build you want, whenever you want, so I think developers thought that illusion of choice will be enough. Really, 150-200 hours is huge amount of free time required to finish TW3.
Mass Effect is directly opposite - it is relatively short, but there are at least two different dialog lines for male/female, and in them there are three choices in every decisive conversation and if you want to experience all that dialogs (and you know that many of them are amazingly voiced with proper intonation and meaningful face&body animation) you need to walkthrough ME multiple times and of course different diverse classes and squadmates will help you in that.
I never forget Shepard's face expression when you are deciding to kill rachni queen in ME1, there is such horror in his eyes, horror that he is killing last reproductive member of that race, to save his world from possible problems.. or when you are in search of Tayne's son and come to interrogation room, if you have enough renegade reputation, you may just say "I'm a Spectre, start talking" and that surly guy start to talk immedeately, though if you went paragon way he will f*ck your brain for long.. and there are dozens or even hundreds of similar emotional moments during ME1-ME3, moments which look more sincere that most of Hollywood modern films.. And there is no way to experience most of that cool moments in one or two walkthroughs.
So I think it is not honest to compare diversity and replayability of Witcher and Mass Effect, first was created for one long walkthrough and second is from the base adopted for at least two of them, and you can freely go for 3-4 of them and have different dialog and gameplay. This all is mostly for ME2, ME1 has less diversity and renegade dialog lines aren't always reasonable, and ME3 lives just as a show of consequences of first two parts and is closing many interesting topics in a dumb and short way.
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What are the tough and grey decisions in ME3. AFAIK, paragon options are always the more rewarding ones in the end.
Grey decision 1 - cure genophage or not. Actually there are multiple scenarios which availability is dependent from your actions in ME1 and ME2 and life state of Wrex, Mordin and female krogan. To receive the best result you must have save with right optional actions from ME1-2, and still one of the brightest squadmates will die. And also you final decision will theoretically influence your relations with salarians;
Grey decision 2 - save quarians or geth or both - and again it depends on your actions in ME2. Without precisely right ME2 save you couldn't save both. So in a plain ME3 or even not ideal ME2 save you must choose between arrogant but alive quarians or clever but mechanical geth;
Grey decision 3 - save your krogan friends or rachni.. yes, that part is awfully implemented, bit it is still there;
Grey decision 4 - despite all the criticism of the ending, I'll say that I hate final mission, but not final results themselves. Green, blue and red endings are quite balanced form point of selfishness - in one you are alive but galaxy is in ruins, in second you become a dead god, world is ok, but reaper threat is not eliminated and in third you sacrifice yourself for a new better life for others.. and it seems that Illusion man's idea was not that bad in comparison to obvious red choice.
And now what are grey decisions in TW3? Save Temeria or Redania?
I won't call ME an "adult game" but at least it didn't oppose common sense in first two parts.. and in third it is generally ok if you manage to close eyes on some details, all the crying is about fact that Bioware made just "okay" when they have all opportunities to make masterpiece.
As for the "waifu" and fanatism I never see so determined hate and mad reactions from any fans of single-player game, but which you can see on youtube from witcher fanboys when someone is saying something slightly bad about TW3 or it's characters. No adult person in clear mind will never threat video blogger because of some game.. all that clearly shows that a large part of TW3 gamers are teens in a period of sexual maturation, which have taken all that far-from-reality story too serious and they are living in it for 500+ hours with the same 3-button gameplay.. that is simply awful and ridiculous and it shows that TW3 doesn't do anything good to their mind.