Okay let's try to analyze Anna's matchup interaction first before we boycott NG. We will only look at the remaining typical finisher/last 3 cards and pick which is the best card to create. This way, it's more consistent for the 3 options.
MONSTER
Eredin - Mourntart, Yrden(sometimes), ?
Woodland - Ozzrel, Speartip, ?
Elder - Elder's gameplay and sequencing is flexible so there's really no constant finisher combo
Arachas Queen - Glusty, Yen
Gernichora - Ozzrel, Geralt, DD, Nivellen
SKELLIGE
Crach - Scorch, Comander's Horn, Wild Boar, Geralt
Harald - Dagur, Ocvist, Regis
Bran - Commander's Horn, Yrden, Kambi, ?
Eist- Dagur, Regis, Bekker's, Jutta, Hjalmar, ?
Arnjolf - Lugos, Dagur, Regis, Svaringe, ?
SCOIA'TAEL
Filavandrel - Sheldon, Lacerate, Aglias, ?
Francesca - Bluedream, Garrison, DD, Nivellen
Eithne - Scorch, Professional, Igni
Brouver - Sheldon, Lacerate, Aglias, ?
Eldain - Pitfall, Iorveth, Isengrim, ?
NORTHERN REALM
Foltest - Regis, Ocvist, Gaunter
Demavend - Baron, Hubert, ?
Adda - Hubert, Ocvist, Sabrina, Blaze
Henselt - Sabrina, Draug, ?
Meve - Hubert, Ocvist, Sabrina, Blaze, ?
NILFGAARD
Emhyr - Leo, Vilgefortz, ?
Calveit - Horn, Menno, Stefan, Vattier, Yen, Regis, Vattier
Usurper - Leo, DD, Nivellen, Horn, Vreemde
Morvan - Flexible sequencing
Ardal - Flexible Sequencing
This is a list of the best possible create for Anna per matchup ( ? = what else? )