Death March, Enemy Scaling on ( don't think it matters for this fight anyway) NG+ Alchemy build , Manticore set , nothing is too hard with those skills . I have 342 toxicity, four decoctions and still room for two potions :
- Griffin ( less damage taken )
- Archgriffin - every strong attack takes 5% out of the enemy HP, regardless what damage you made (after the damage is applied)
- Chort and Noonwraith decoctions to prevent stun and all the other shit
With the Fast Metabolism skill your toxicity from potions goes down very fast, also there is another skill that heals you 50% every time you take a potion , add to that long potions duration, some 15000 hit-points or things like white Raffard Decoction ... you can fight that thing for half an hour whit out getting killed
i think with the Legendary GM Ursine Gear is even easier since i saw 80% damage reduction from monsters while Manticore has 57% , the reduced 35 toxicity is not that important since i could still take a potion and its toxicity is over in 5 seconds . Is there a limt to how much damage can you absorb ? I mean ... Ursine + protective coating from oil tree offers 105% damage reduction from monsters if you have the right oil on your blade .