Apologies for resurrecting an old thread, but just in case anybody is wondering if this problem still exists: Hoo, boy, does it ever.
I downloaded the Enhanced Edition that was released together with the RedKit (so what's that, now ... version 3.5, I believe?) and played through the whole thing using my dual Radeon HD 6970 in Crossfire setup. Of course, the problem with Radeon cards in Crossfire has ALSO never been fixed ... but that's a different issue.
Anyway, I bought myself an NVIDIA GTX 680 card, and since The Witcher 2 is one of my favourite games and also graphically quite demanding (if you configure it to be), I thought I'd use it to benchmark the difference. Well, ever since the switch from the AMD card to the NVIDIA one, there is just no getting past the 0xc0000142 error.
No, I don't have any funky toolbars. Yes, I even tried with the msconfig "clean boot" (removing everything but Microsoft services). Yes, I've utterly and completely uninstalled the dot NET framework, run the cleaner, and reinstalled it.
No go.
CD Projekt RED, man, I gotta tell you: I absolutely LOVE your games, but you have one hell of a long way to go when it comes to cleaning up your releases. I'm in love with just about every aspect of your business, I can't wait to buy the Witcher 3 as well as Cyberpunk 2077, but I just already have that yucky feeling that if something should fail to work, it'll be on me to fix it (i.e. "try different hardware") because your efforts in that particular department are sorely and terrifyingly lacking.