I'm having the same issue after installing patch 1.05. Loading any of my saves results in an infinite loading screen.
Starting a new game comes with the same result.
Changing display settings hasn't affected it. Removing the user settings, and resetting hasn't had any effect, either.
Loaded the latest AMD Beta drivers (previously was at the latest non-beta), to no effect.
Attempting a re-install.
Current specs:
Win 7 64 bit
AMD FX 6300 6-core CPU
AMD Radeon 290, 4gig vram
8 gigs ram.
AMD something something motherboard