OK I got a multi arch amd64/i386 Debian Jessie/Sid up and running!
I'll try to run some Steam games and report.
Some Steam tips on Debian amd64:
1. Download and install python-xkit and jockey-common from the Ubuntu repos. These should install without issues in an up to date Debian.
2. Download Steam from their website and install.
3. Run Steam. It will alert you if you're missing 32-bit libraries. In my case: libgl1-mesa-dri:i386 libgl1-mesa-glx:i386 libc6:i386
3.1 Install missing libraries.
4. Run Steam! It is currently downloading 152,8 MB of *something*. I'm guessing it's the Source engine and the main application. After all the Steam deb is only 2.5 MB.
** Update
Got fed up with a library issue last night and stopped. So I fixed it today. It was simple: Steam could not find my 32-bit DRI libraries and games weren't displaying properly. Since I installed the required 32-bit mesa libraries after I installed Nvidia's proprietary drivers, I simply reinstalled their drivers to override whatever mess the first did. And so the new error Steam showed me was simply "cannot find libGL.so". Apparently Nvidia installs its 32-bit compatibility libraries somewhere weird, so I just set that route in LD_LIBRARY_PATH and voila, Steam for Linux works on Debian Testing amd64!
I tried Osmos and Galcon Fusion and both play well. Now I will try And yet it moves. I also have Trine 2, Stacking and Portal available, plus all the Humble Bundle Steam keys I never redeemed

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Wonder how much attention will this think bring to the Linux gaming scene?
Edit: I experienced some sound glitches and distortion in most Steam games, even when their DRM-free counterparts from the Humble Bundle didn't. I found a solution that might work in most cases. Apparently it has something to do with OpenAL and PulseAudio (I always suspect PulseAudio). Simply create a file called .alsoftrc in your home directory and add the line:
to use ALSA instead of Pulse. This solved it for me, and now games sound perfectly. I recently tried Anomaly Warzone Earth (from the Bundle) and it runs fast, fluidly and is different and fun.