One would absolutely be needed as they own the copyrights if you plan on using the "Cyberpunk 2077" phrase, logo, etc.
If you are talking about cyberpunk in a general sense, just have to tread carefully. If you create and sell anything too close to what they have protections on, that can still get you in trouble. For instance, you make a character similar to Johnny, but with some changes to his face and arm, it could still be deemed close enough to his image and land you in hot water. If you make a general character that has nothing to do with the game itself, but has a cybernetic face, that should not be an issue as long as you don't use material that is covered under the copyright.
You'll have to write or email them to see if they will even allow use of their property at all, and if so, who you would specifically have to be in contact with.