I actually succeeded with the autopsy on my first try, and thought... hey, that was pretty easy.Had to revise that first impression eventually. "Eventually" being on the 4th playthrough.
I thought it was pretty neat how you could get 4 or more different conclusions during the playout of the chapter. All the while i`m sitting there and thinking OH CRAP i really hope it`s not this one or that one
I actually heard that politics comment on my first playthrough, but I didn't think much about it. Felt utterly clueless all along, until the whole thing sort of worked itself out when I found the guy dead.