At least 6 full runs. 2 full runs after original release. 2 full runs after 2.0. 2 full runs after EE. In between, I've restarted chapters or loaded certain saves to make different choices to the various decisions points just to see what happens ( kill Aryan|let him live, take different routes inside the La Valette dungeon, kill the troll|don't kill the troll, attack prison barge|ruse, etc).