Humor is an human trait, I expect it to be there in the game, people will make fun of you, or whatever, mostly in a shitty place like Night City, a good laugh is one of the few free thing you still can get.
Anyway I'm not very worried about it, Cyberpunk 2077 won't be a sitcom, unless guys at CDPR started replacing water by alcohol.
The "I don't take myself seriously" as a game can work for an over the top universe like Fallout, it wouldn't fit Cyberpunk.
Just like if Decker would be all "Dick out for the replicants" at the end of Blade Runner... Kinda anticlimatic.
I'd rather have some "cool attitude", just like in good Scifi flicks, like in Aliens movie or Robocop, people being people, some had a good day, some a shitty one.