So here is a little feedback concerning the beginning of Act 2. This is where the map opens up completely and all the side quests become available. However, in my opinion that happens a bit too early and can break immersion in regards to character arcs. Specifically,
I don't exactly know how you would solve this issue, but maybe there is a way to "force" the player a bit more towards the main story until
and only then open up all the side quests.
V and Johnny Silverhand hate each other at this point in the main story. V even blocks him with pills. In many of the side quests, Johnny and V interact as partners/friends though.
V and Johnny are somewhat comfortable with each other