What about the "piece of lembas" line from Iorveth in Act 1? Not too many picked up on the reference. It's easy to latch on to the more obvious ones and cry about that but honestly, there's nothing wrong with some humour now and then. Whenever someone says that The Witcher 2 is pretentious (they have to be some kind of morons but hey, there's no accounting for tastes right...) I point to the scene where they're talking about the one ring. It's great because it shows the absurdity that magic brings about and it shows some of REDs personality. They're not so rigid and stiff as not to crack a joke sometimes.
I didn't have problems with the so called "in-jokes" or "easter eggs" or "pop culture comedic references" or whatever. I was playing a polished game with well written characters, developed plot, a beautiful and believable world and excellent voice acting. A mere sentence is not going to break immersion for me in such an amazing game. If it was a shittier game, then maybe. But for a game of this quality, it takes a little more than a joke to do that. Maybe some people need more for them to be hurled out of the experience than others. I for one had nothing against the easter eggs. I loved them. Most of them were subtle as fuck, while one or two were quite obvious. No big deal.