All the romance options sexuality doesn't bother me except one. Panam's, and it's not really her sexuality that bothers me.
See the others, Judy included, fine they have their preferences. Great, it really doesn't matter in the storyline whether you romance them or not. Judy kind of sort of, changes one part of the ending, but not really. She just gets more screen time at the end then the other romance options, but really it's just fan service, nothing more. But really, meh, let them have their sexuality.
Panam's on the other hand, seems to neuter her story slightly, all in the name of making her straight. She's literally central in part of the main quest, and if you do her side quest, is the only romance option that a real part in the final quest and ending.
But for some reason a female V can't experience the full Panam storyline, because.. well... the devs decided to arbitrarily make her straight. As a female V I hate it when you don't have the option to experience an entire part of the main storyline because some troglodyte decided to gender lock it.