Yes, something could've been done with the blueprints before Mikoshi. After? No, because V is dealing with a neurological problem (immune system attacking its own neurons), which means the blueprints and the Relic are out of the equation.B) the blueprints that V inexplicably decides not to share with anyone (really, V, you're not gonna show Vik, your literal doctor? Or Judy, a neuro-tech specialist (who casually innovates difficult brain tech, btw)?? Or Rogue with all her resources???).
Furthermore, what V's body is suffering from sounds exactly what Multiple Sclerosis does - the immune system attacks the nervous system. There is an in-game news report about Multiple Sclerosis and BioDyne Systems. It describes a nanite treatment, that when injected into the spinal cord, repair the neural tissue. This could be a possible solution for V's problem in the future.
In the tabletop lore, the Aldecaldos are allied with StormTech, who have facilities in the Crystal Palace, so that's a potential contact and a destination for V.I'm guessing they're going to focus on Panam since she flat out says she thinks she can help you with the Relic (as far as I can tell, it's never explained how - correct me if I'm wrong) and Mr Blue Eyes.