I really hope some things.
1.To really use 64-bit goodies, not just 64-bit executable
2.Don't be a CPU demanding or a GPU demanding game, use them together
3.I hope they will not screw DX11 to have bad performance/stutter/etc. in DX11 mode (see Dragon Age 2 in DX11 issues, still today, DX9 runt great on DA2)
4.I really hope they manage the CPU and GPU to work optimum(the same usages), i really hope i can max this game on my 680 @1250mhz, without AA or ubersampling.
The essential thing, is how they improved the new RED Engine version, if it's almost the same as the one in Witcher 2 + DX11 and DX11 effects, will be ok, we can run the game proper as Witcher 2.
5.I hope they manage to smooth the open world LOD, AFx16, jaggies, on-the-fly loading textures in while you travel in open world, this is very important, CDPR, look at my post, i know what i am talking !!