This doesn't sound like the same issue. When your game crashes, it generates a crash dump file, I can't remember where but it lets you view the dump file from the popup window that says the game flatlined. Have you read that dump file, and can you copy/paste it here?
No it didn't seem like the same issue to me since none of the saves would load at all, but literally nothing else has changed on this system. That said, without thread or debug info it's impossible to say, but I looked up the dll at the bottom of the stack here and it might be GPU/driver related? Very odd... again haven't changed a thing here... (edit: I take that back. I changed RTX setting from high to psycho today, but just kept playing instead of rebooting. That is the only setting I changed, and I changed back after the load save failed... obviously did not fix by reverting the setting).
EDIT: Unfortunately I don't have any more time to spend on this today, but it's worth mentioning that obviously I have tried resetting all settings to defaults, reinstalled the GPU driver, and "re-installed" the Cyberpunk2077.exe by .bak-ing it and letting steam re-download it. And it may also be worth mentioning that after letting steam re-download the .exe (same file size) it got much further than it had before (loading screen and progress bar)... guessing something (almost certainly in render pipeline) is corrupted (texture files maybe?)... wil try reinstalling game later, but I want to be sure my saves are backed up first.
Error reason: Unhandled exception
Expression: EXCEPTION_ACCESS_VIOLATION (0xC0000005)
Message: The thread attempted to read inaccessible data at 0xFFFFFFFFFFFFFFFF.
File: <Unknown>(0)
Version=1
EventType=REDEngineErrorReport
EventTime=0
ReportIdentifier=ffffffff-ffffffff-00000001-00000000
Sig[0].Name=StackHash
Sig[0].Value=0x0000000000000000
Sig[1].Name=ErrorReason
Sig[1].Value=Unhandled exception
Sig[2].Name=InternalVersion
Sig[2].Value=3.0.3233390 P4CL: 4173226 Stream: //R6.Root/R6.Patch0Hotfix2
DynamicSig[1].Name=OS Version
DynamicSig[1].Value=10.0.19042.2.0.0.256.1
LoadedModule[0]=Cyberpunk2077.exe
LoadedModule[1]=ntdll.dll
LoadedModule[2]=KERNEL32.DLL
LoadedModule[3]=KERNELBASE.dll
LoadedModule[4]=USER32.dll
LoadedModule[5]=win32u.dll
LoadedModule[6]=GDI32.dll
LoadedModule[7]=gdi32full.dll
LoadedModule[8]=msvcp_win.dll
LoadedModule[9]=ucrtbase.dll
LoadedModule[10]=ADVAPI32.dll
LoadedModule[11]=msvcrt.dll
LoadedModule[12]=sechost.dll
LoadedModule[13]=RPCRT4.dll
LoadedModule[14]=SHELL32.dll
LoadedModule[15]=ole32.dll
LoadedModule[16]=combase.dll
LoadedModule[17]=SETUPAPI.dll
LoadedModule[18]=cfgmgr32.dll
LoadedModule[19]=VERSION.dll
LoadedModule[20]=bcrypt.dll
LoadedModule[21]=WS2_32.dll
LoadedModule[22]=OLEAUT32.dll
LoadedModule[23]=icuuc.dll
LoadedModule[24]=XINPUT1_3.dll
LoadedModule[25]=HID.DLL
LoadedModule[26]=icuin.dll
LoadedModule[27]=bink2w64.dll
LoadedModule[28]=dbghelp.dll
LoadedModule[29]=PhysX3CharacterKinematic_x64.dll
LoadedModule[30]=PhysX3Common_x64.dll
LoadedModule[31]=PhysX3_x64.dll
LoadedModule[32]=PhysX3Cooking_x64.dll
LoadedModule[33]=PxFoundation_x64.dll
LoadedModule[34]=POWRPROF.dll
LoadedModule[35]=d3d11.dll
LoadedModule[36]=redlexer_native.dll
LoadedModule[37]=libcurl.dll
LoadedModule[38]=WLDAP32.dll
LoadedModule[39]=CRYPT32.dll
LoadedModule[40]=Normaliz.dll
LoadedModule[41]=amd_ags_x64.dll
LoadedModule[42]=WINMM.dll
LoadedModule[43]=Galaxy64.dll
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LoadedModule[50]=VCRUNTIME140_1.dll
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LoadedModule[52]=oo2ext_7_win64.dll
LoadedModule[53]=icudt.dll
LoadedModule[54]=IMM32.DLL
LoadedModule[55]=UMPDC.dll
LoadedModule[56]=gameoverlayrenderer64.dll
LoadedModule[57]=PSAPI.DLL
LoadedModule[58]=CRYPTBASE.DLL
LoadedModule[59]=bcryptPrimitives.dll
LoadedModule[60]=kernel.appcore.dll
LoadedModule[61]=windows.storage.dll
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LoadedModule[139]=Windows.Perception.Stub.dll
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LoadedModule[144]=drvstore.dll
LoadedModule[145]=SPINF.dll
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LoadedModule[147]=nvcuda.dll
LoadedModule[148]=nvcuda64.dll
LoadedModule[149]=dcomp.dll
LoadedModule[150]=dwmapi.dll
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LoadedModule[152]=WINSTA.dll
LoadedModule[153]=Windows.UI.dll
LoadedModule[154]=WindowManagementAPI.dll
LoadedModule[155]=nvrtum64.dll
LoadedModule[156]=nvptxJitCompiler64.dll
AppName=Cyberpunk2077.exe