I recently deleted a whole mess of saves from the save folder and didn't see any ill effects. In fact, those saves were about 6 Gb worth of space. Even now, I have about 1.5 Gb worth of saves in there.Note that the game keeps every save you make, not just manual saves and quicksaves, but also autosaves from the moment you start playing.The huge amount of saves also contributes to the amount of time it takes to get into the load/save screen ingame.I say keep what you want and delete the rest. It's easiest from the OS, but make sure you sort them from "date created" so you know you're deleting those that are older than your current saves.I was a little uncertain about the one that's in a folder. I just left that one alone.