I know. Its just annoying. I'd prefer it I it was end of turn but only 1 unit can have resilience (similar to Bounrty. At least you could purify it. Anyway it is what it is.It has no time to; the Resilience is only applied at the end of a round. You do see the animation for it in the background when the board is getting cleared.
The card is as far from trash as we are likely to get. It puts 10 raw points on the board and gives incredibly carry-over value. If you win on even with She Who Knows on board, then your opponent will most likely need to go two cards down (or use his leader ability) to keep up with you. As to Block or Poison - of course, you can do it, like with any other card. The card is very strong, but it is not invincible. However, judging by how many people include her in their decks, I would venture a guess that she is considered a pretty useful card.Sounds logical but then this card is Trash. Just Block or Poison and GG