With six months to live, a romantic partner who loves her, and an enormous fortune, V decides (with no input from player) that merc missions are the thing she wants to do with her last six months of life. Why? Yes, this was what V wanted at the *beginning* of the story sitting in the limo with Jackie, but the point of character arcs is change. This was the point that V has learned what's really important, and that she wants love and friendship more than glory. (Or at least that choice should have been ours to make.)
I keep hearing that V's goal is to make a name / be remembered, but don't know where that comes from.
Jackie wanted to make it big. V was along for the ride until s/he got in too deep to get out.