This happened while doing the space between quest where you visit Clouds to try to find Evelyn. After completing the quest in Clouds and leaving, there is an interaction where V gets sick due to the engram and he has a conversation with Johnny about next steps. During this dialogue interaction, the HUD and UI do a sort-of glitchy shifting like V's cyberware is malfunctioning. The problem I am having is that this HUD/UI glitch didn't go away after the dialogue interaction was done.
I have no autosaves or save files that predate the bug (I know I should have tried to roll back sooner) and I effectively have to start my entire game over after 20 hours of play. I tried all the tricks of drinking alcohol, triggering a cutscene, restarting game and computer to no avail.