Actually the new grid system is only said to be planned for the inventory. So if that was your problem, then it is already solves, as for the "hands" and the orange glow of the herbs, as far as I know the loot symbol (at least in the alpha version) is less intrusive this time and I am sure the herbs and enemies you can loot will only "glow" in Witcher sense, so I think that is solved too.
If those were your only concerns then I do actually not get why you are for auto-refilling and against the full-manual system. Yeah, sure, less herbs to collect is something that should be done, but in one of the "versions" stated they do let you collect a lot of herbs for the first time and then reduce the amount for every time after that unless you want to upgrade. Which is IMO a perfect compromise. That way you need ingredients, but not as much so it is not tedious for people.
Also with potions having 3 uses it is also made easier and it takes longer before you have to refill. Also, we do not need auto-refill. If I want to refill a potion I just meditate and refill it myself. If auto-refill is in it means every potion I made 1 time will refill which is bulls**t considering I might not want to use/refill some of the potions because I do not like them as much as other potions. IF - IF refilling means that you - in case you have used 2/3 uses for a potion and got 1 left - can "thin" the potion out in order to "refill" the 3 uses and then use the potion 3 times again (but with less effectivity (+5% of X instead of + 10% of X for example)), THAT would be okay with me, as long as it does not auto-refill but let me "refill" it myself and give me the choice to either refill or just collect ingredients and create a potion with full effect again.
I think the upgrade system would be for the exploration, the long time motivation, and give the potions more of a sense and use over time even if you already grew stronger (especially if we can use all versions of the potions - the weak ones and the strong ones - whenever we want), while the ingredient collecting for single potions is made easier by reducing the needed material and giving you 3 "charges" for the potion, which is great in order to not make the potion-brewing and collecting TOO tedious and frequent. It's the perfect way to go IMO.
The question, however, is if this is the version CDPR have at the moment, because as of now we have 3 versions flying around and no one is 100% sure which one they are working on and implementing at the moment....