This is my opinion only. I'll add more to it if I think of any. The big things I want in The Witcher 3 are:
1. Property: The ability to buy, own, and manage property. Stores, houses, maybe even a whole city or village. The arguments I've seen against this say that Geralt is a nomad. That is very true. However in the games, Geralt is what you make him. If you want him to help people, that's your choice. If you want him to wander from town to town, inn to inn, you can do that. You should also be allowed to buy and own property. Because it's a choice that some players will want to make.
2. Auto-saving: I don't know if other people have a problem with this but, the auto saving was a big hassle in The Witcher 2. I didn't mind that it saved the game constantly, that part was useful. However the game didn't overwrite previous auto save files. I had thousands of save files that I didn't want or need. Please cap it at 3 or four. And allow players to label each manually saved file. For example, "Playthrough 1" or "asdfjkl;" or what ever the player wants to name it.
3. Inventory: The Witcher 1 had a tiny inventory that made carrying things difficult. The Witcher 2 had a large inventory that was difficult to navigate. I like a large inventory that's easy to navigate. Making it a slot inventory with thumbnails for the items would be good. But get rid of the weight limit, it was really annoying. I would like a stash to place things and the ability to obtain more space to stash my stuff. For example: purchasable chests, boxes, or even a storage house.
4. Platforming: Not really important to the game, but I think free climbing and jumping around/on a mountain or abandoned castle would be really cool and add a new dynamic to the game. The idea of puzzle solving would be an incredible addition to the game as well.
5. Mercenaries: Hired help would be a welcome addition, in my opinion. Different mercenaries have different skills. You could hire an archer to cover you while you hunt small fries, a beefy guy to help out against a troll, or if you're not confident enough going into a dungeon, bring along a hired mage.
6. Multiplayer: I'd support it as long as you could create and design your own witcher or other class of character. Gender, face, clothes, weapons, race, everything. There could be different modes and maps even. Just fighting with swords and magic instead of guns and bombs. Also multiplayer must not take away from the main game, at all. So I'd like ask that, if CDPR considers it, release multiplayer after the main game has been released. Like you did for the Witcher 2's arena system. That way the main game is complete and up to snuff and you can work on other things at your own pace.
7. Mounts: Being able to buy a horse for combat or a mule for a traveling inventory would be immensely helpful. In open areas a horse is a needed advantage and when traveling on the road a donkey would be good for carrying the less important items.
8. In-game options: Managing graphics, sound, and gameplay options would be a lot easier in one of the in-game menus instead of the the start up window.
9. Large cities: If the game is going to be open world, as it says in the article in game informer, then there should be large, beautiful environments. Big cities full of people and venues; large plains and forests. They need to be almost fully interactive though, otherwise what's the point?
10. Environment: Add some more darkness and horror to it. A low growl in the background or wind shaking the trees. It will give the game some more life and keep the players on their toes. Also let Geralt explore the world. Let him sight see, visit places in the books, run into old friends, foes, and places. Kaer Morhen is a must.
11. Quests: The quests are great. I'd like more of them though and I'd like them to be more open ended. Also the quest tracker needs a lot of work.
12. Ending: Once you beat the game don't end the game there. If Geralt has finished the main quest let him continue to have fun and roam around the world. Also, please provide at least one happy ending.
13. Sequals: I hope this is not the last game. The series is just so good and so well done. It would be a shame to end it here. Not when they can take so many different routes in the story.
14. Internet: Please don't make the game require an internet connection to play. Some fans don't have access to a constant internet connection and would like to play but can't because of that.
15. Buying/Selling: Offer a description of what Geralt might buy so he doesn't waste money on something useless. Add in a barter system so he might get a better price for an old sword he's selling.