I think the only way to use exclusive fullscreen mode in a Unity engine game is to add the -force-d3d9 argument when launching the game, and I'm not sure if TB supports that. You can give it a try.
Another fix you can try is to disable v-sync in-game and use a frame rate cap to match you monitor's refresh rate. How you do that will depend on the video card you have. I use nVidia Inspector with an nVidia card and set the cap with a profile.