I would say a good change would be to do like I said. Just spawn random street workers all over town. They don't have to be packed in there, but they should be pretty common. Meanwhile in some areas (near the sex shops that we can't interact with) there should be a lot more. And you should also see Mox guards near those in their territory, because THAT'S WHAT THEY DO.
Along with the random joy toys you can have fun with (with the short cutscenes), there should be fun to be had at clubs and such. Lap dances and the like. Actual strippers working the poles and such.
And the Brain Dances, which were SUPPOSED to be in the game but got removed for some reason. Again, just add some different scenes, and let players by BD's by scene with various characters in them. It's just using stuff that's already in the game. Just make it vastly better.
Have V able to become a regular, where if you visit the same joy toy enough times, you start getting some special dialogue. Maybe even add in a few little quests for them, like picking up something they need, helping out a friend, or even a rescue at some point. Which would trigger after X amount of visits.
It would make the world feel a lot more alive in that regard. And fit vastly more with the setting than the game does now.