We've used it a few times. In one campaign (Merc team in 4th Corp war), we ended up going to the Crystal Palace to do a job, but it was a low key job with low powered weapons (don't want to puncture the skin of the habitat...), we then had to bug out quick and ended up in Central America with hardly any weapons and had to deal with a cartel to get more weapons. I could have hit the player who said "we have no guns'.... Massive firefight then happened, and somewhat one sided (at least my sniper was perched a little over head, but sadly with only a revolver with sub sonic rounds (no long arm due to the space trip, same with the sub sonic rounds). But we did have access to some 'Crazy Ivans' (Kinetic kill satellites).
Also has access to a mil spec laser kill sat in a Cop campaign (just my character, a, ex con who was a netrunner, who turned good and became a cop, then we all got set up and went on the run, at which point everyone else realized I was previously a con.. .ah fun times. Also took out the most kills in that campaign, I used the kill sat to take out a navy battle cruiser that was on to us... lol).
I briefly ran a space based game, with the sci fi twist that there were aliens. The players were crew upon a long range deep space supply ship (think something like the huge refinery ship in Alien or the Discovery One from 2001) . Can't remember the year but it's set something like 2200's or something. They get back to our solar system to find that their space station out at Jupiter had been attacked by aliens. It was a first contact scenario that didn't go well for our side.
We ended up ditching that campaign simply because we had too many games (CP2020 and others), and needed to eliminate a few. That one had only been going for a month or so so it got ditched.
It's been used a couple of other times, but only as a 'side quest' or for a 'fish out of water' mission.