1- more fleshed out characters:
there are so many great characters (such as Evelyn, Jackie, T-Bug, Dex etc) that were all wasted and underutilized. but it seems the writers pushed Panam down our throats because her quests are infinite.
2- the city to be more alive and real, which means NPCs with schedules (like it was in TW3?) and more responsive to you. they just wander around aimlessly like zombies and serve as a decoration for a pretty painting, the city
3- the story to be more about V than Johnny Silverhand. on second act I really felt like my character took a backseat so we can dive into JS's world. it also seems like all characters mentioned previously had their arcs cut short to make room for more JS...just a feeling.
4- choices and consequences, choices and consequences, choices and consequences, choices and consequences
5- choices and consequences