I play mostly non-lethal, and there are lot of gigs (some main missions too) that ask you to be discrete. A fair amount of side gigs give you a huge cash bonus at the end for not killing anyone. There's also a side story mission that I can think off the top of my head where if you make dialogue choices to keep everything non lethal then it impacts 'news' you get later on about certain NPC's (trying to be spoiler-free here).


