While it's not a fear per se, I'm a bit curious how 2077 is going to handle the impacts of AI and Transhumanism. So much futurist Sci-Fi portrays it's characters as 20th century archetypes with some shiny gadgets. Just look at Star Trek. Most stories never consider the feedback loop of tech changing us and us changing it.
One of the things I enjoy so much about BLACK MIRROR is that it intimiately examines the transformative effects of technology (positive and negative) on the human experience or even what it means to be human. Look at society pre and post internet.
I understand that Cyberpunk isn't a game about Transhumanism. But it would be difficult to imagine that AGI (or even ASI) won't exist by 2077. Even if augmented human intelligence doesn't advance, being able to think in digital timescales would change everything. Bostrom is onto something regarding this topic, and I'd love to see CDPR take some of his thoughts into consideration. And once AI start designing things, the era of human invention is over. I hope that the impacts of automation on human workers is conveyed in 2077.
Separately, I'm very curious about the potential of Netrunning. I'm praying to the robot overlords for more than just hacking mini-games. The narrative potential is immense when you consider the implications of full sensory immersion. Players could be in virtual environments and not even know it. Players could BE AI and not know it. So many possibilities. And in such environments, the physical rules of meat space don't have to apply.
Of course, no project can deliver on every dream. These things may be big asks from a dev perspective. CPDR are intelligent people. I'm surely not saying anything that you guys haven't considered already.