Panam, she has a fire in her that is hotter than the sun but she won't burn people who get close. She's the personification of the human spirit and the antithesis of Night city, the fact that V very early on into their relationship encouraged her to stay with her family and give up on the Night city pipe dream is so powerful. You get to save her life as soon as you meet her.
Judy is a close second, a closed off and introverted person, held her cards close to her chest and only let those she trusted see them. Dealt with nothing but pain her whole life but only cared about others. She even perused her work with BDs in the first place to bring whatever happiness she could to Night city without having to leave her shell or reveal her hand, yet she took a chance and let V in. Adorable and should be protected at all costs.