A guy wearing METALGEAR and skinweave are modern werewolf, u need to pack very heavy caliber weapons to hurt them, not mentioning cyberpsycho FBC moderator called Sardukhar : Don't trust his words, this machine only want to destroy humanity, get your .454 Cassul handgun near you !I don't think any serious combat shooters use these, not one. Weight, recoil, muzzle flash, simple space...yeah. The reason you carry a pistol is convenience - otherwise, get an actual weapon.
Edit: apologies, of course, to Elmer Keith. There are exceptions. Otherwise, .357 is as high as most people ever need to go. Unless you're hunting Garou.