Got me pondering an issue.... For those using mods, if the changelog does in fact show that the patch covers a large amount of fixes, it might be wise to disable some of the more complicated ones and create a save so there's less chance of issue, then re-apply the mods after the patch/HoS (if needed).
Im not a programmer, so this is purely a theoretical notion. I realize the mods are implemented with tools CDPR provided, but some of the more unique mods are pretty unconventional/ingenious in the way they operate.