1- Which gender are you gonna play as ? Are you gonna pick female V ? Male V ? Both ? and if both which one will be your 1st playtrough ?
2- Do you know what kind of character are you gonna make ? and I don't mean background story and choices . Those were covered in another thread already . But how will they look ! Who gonna inspire you to make them ?
1 - First run a Male, CDPR really made male characters appealing (outfits, style, etc...) kudos for it, most of the time they look kinda bland, but here there's a lots of "Shit, I'd love to have a dude like that" moment for me, I really liked Jackie's style and what I saw until now, so most likely a male (just to play the game as if it was myself, better imersion).
Then probably a Female, just to see the difference between both genders.
2 - Of freaking course: