So it was a live video about asking a quest designer from CDPR. I will write down the "most important" Q&A.
First of all he said: Witcher 3 Blood and Wine will be
the last expansion for Witcher 3. The reason: "you should stop when it is at its best."
Second question: Could you imagine a woman as a witcher for future witcher games since Geralt is about to retire?
Answer: Yes we could imagine.
Also they said developers would like to work on a new project since they started working on the witcher series since 2002.
New skellige gwent card faction as mentioned some posts above.
Question: Will there be a gwent card game? (I guess standalone like Heartstone)
Answer: There were several discussions between developers about that but at the moment there is nothing planned beside blood and wine.
Side information: Witcher 1 & 2 were planned as open world games already but there was no possibility to develop them as such.
Question: Will there be (in blood and wine expansion) characters from the books we havent seen so far?
Answer: There will be new characters and characters we already met in the game.
Question: So new characters from the books?
Answer: Maybe?
Question: Hardcore mod with only one life?
Answer: Not planned maybe in the future.
Question: Did you improve the graphics and optimization for blood and wine?
Answer: Yes, after main game feedback there are several improvements.
Side question: Graphics compared to first gameplay video back in 2014, better ?
(guess its this one but im not sure!): Thanks
@TheImpZA
Answer: Yes, in my eyes!
Improvements Toussaint: vegetation, textures (people will be very impressed seeing toussaint for the first time)
So this is all I got about the new expansion and general witcher game. About map size I didnt hear a thing.