I'm going to take a slightly different approach to answer. Rather than just saying what I hope happens, here are a few points I think need to be answered. How they are answered, what choices we have, that's up to CDPR (who will probably be awesome, as usual).
Emhyr. /spoiler, obviously (you shouldn't be in this thread if spoilers are an issue). Geralt is absolutely intimate with secrets Emhyr does NOT want running around. Geralt knows about Emhyr's monster-guise past (Duny). Geralt was there when Pavetta wrecked half the castle to protect her lover, and very much shaped the present that day. Geralt, through the law of surprise, became Ciri's guardian. He stepped down from that responsibility, and had it shoved back into his face. Whether he likes it or not, he is now as much Ciri's father as Emhyr. Well, apart from the part where he plans on impregnating her... Which Emhyr backed down from. Emhyr fully planned to do what he rationally thought necessary, but when push came to shove, his emotions, his human nature, made him abandon his plans. Geralt knows this, and Emhyr only let him go out of love for his daughter (the very reason he didn't proceed with his original plan in the first place).
Emhyr is still a most potent player on the board. Still, precious few people know anything about this. As far as the average person is concerned, the girl he's with is the lion cub of cintra - which means that not only does no one realize the girl is a fake, but no one even realizes that Cirilla is his goddamn daughter. Everyone thinks the emperor is married to the heiress of Cintra, and no one even knows that the Emperor is technically the legitimate ruler of Cintra.
That, right there, is one subject I think should be answered. We'll probably run into Emhyr, seeing as he as a voice actor and all. I trust CDPR to make that encounter memorable. But still, he has a shit-ton of reasons to not let Geralt go.
The other major encounter I expect, but on which I won't really go on about, is Yen. There are a ton of threads here on how Yen should fit in. I won't elaborate. All I have to say, having read the books, is: if Yennefer is anything like her original self, she isn't going to go all Shani/Triss on Geralt. There won't be any "Choose me or lose me" dialogues. If I know Yen, she'll walk up to Geralt and tell him everything has been seen to. And it will have. Yen has already given Triss one fair, solid warning about Geralt in the books. Knowing Yennefer, she'd kill Triss straight up if she heard about what happened in TW1/TW2. However, Triss' behaviour during the pogrom which (should have) cost Geralt his life is, if she has the means to remember it, the one redeeming grace she should have in Yen's eyes.
Triss put her neck on the line that day. And she did so in the most uncharacteristic way possible. She was back to the wall, and she delivered. And she did so knowing full well that Geralt was not hers. And that, to me at least, should at least give her a second chance in Yen's eyes, assuming she remembers that episode at all.
So in the end: Emhyr and Yen both need to tie up some loose ends. And that should be awesome.