I've noticed sooooo many things I can't pick up, here are 3 items I can't pick up just in the part I'm at right now. As a pack rat, this really irritates me.
There is generally a problem picking up almost all loot, you have to walk around, jump around, etc., to get the right angle sometimes, so when I find unlootable loot I spend ages trying to find the perfect angle which doesn't seem to exist.
It reminds me a lot of the Witcher 3 loot system, it's so annoying. If there's going to be so much loot in the game then it should be easy to pick up, or at least a mod that enables auto-looting when near loot so you can breeze through the looting of crime scenes and get on with the game. We're going to loot everything anyway right? I would pay any amount for that mod.
But if the devs thought looting in this way was good enough all these years, I doubt they're going to improve it now, not with all the Class A bugs CP has, the least of which the bricking of save files that reach 8mb. >_<