Life paths having more effect on the story. Or getting more unique mods/weapons. They really should have more of an impact. Examples being streetkids get more from Rogue. Nomad more from Pam, and Copos with Arasaka.
Relationship with Claire.
Claire also helping customizing cars. Or Delamain.
A garage that can take all your cars, and some smaller ones for your apartments, where your car/s for that area returns (where they are selected to be).
Shooting from cars/bikes. You can hack, but not shoot?
Ng+ mostly just to keep items, or get doubles for your wall, and field use.
Cybernetics implants that give attribute points (for example gorilla does body, rocket arms for tech, mono cool, and blades for reflexes). You take them off the extra Attribute points go, and the same with the perk points earned with, but you get them back, if reinstalled. It just makes sense. The biggest being the Gorilla arms, should give body, fixes the door opening text.
Mega build Judge Dread like quest line, that lets you "join" MaxTac, NCP or both, then quest lines for joining them. I mean y'all have those buildings, and it doesn't even have to be all in one. Perfect start be in your very own home Megabuilding.
More quests with your romantic options.
Random encounter quests.
Using flying vehicles (probably have to be a put into an expansion).
Not the least, but biggest let us craft all levels of mods again, or just let us use them like before 1.5 for clothes.