although the game mechanics are almost fully explained, there are still parts which i don't know. unfortunately i have to check everything myself by trial and error and pure logic mostly. CDPR is very busy, they answer questions after few months or not at all because after so much time developers responsible for game mechanics mostly work somewhere else so some parts of game mechanics might remain secret forever unless players understand them.why creatures are so resistant to critical effects when using steel sword is a mystery. they takr 4x less damage from steel attacks but it's possible, logical and would explain this issue if steel resistance would also pass to any other multiplier and modifier from steel style attacks. so f.e. ghouls attacked by steel sword would be 4x also 4x more resistant to critical effects like bleeding. makes sense to me.toxicity is another mistery. after 1.5 year from game release 95% of the game scripts are still unaccessible and thus unmoddable and secret. i only know from game experience that toxicity >50 lowers accuracy (attack), dodge, parry. at some point it disables the use of signs, causes high damage to geralt when drinking another potion and possible make potion effects weaker, like slower regen from swallow potion. unfortunately i can't support these statements with numbers or proofs, you can just check it yourself and observe same effects. by rule of a thumb i guess that accuracy, dodge and parry penalty equals 50 which is a lot. it's not a percent, just a number which is substracted from your dodge, parry and attack value. generally 50 lower dodge and parry means around 50% less defense.this is parry for example[size=6pt]dex parry +bonus[/size]2 55 663 65 784 75 905 95 114then confront it with enemy attack - accuracy. let's say that enemy has 100 attack, you have 95 parry. enemy has 5% chacne to hit. now substract 50 parry from toxicity penalty. enemy has 55% to hit. huge difference.altered metabolism doesn't remove toxicity penalties, it just makes them less painful. is it worth it depends on player style. some players for example find buzz perk extremely usefull. they trade alcohol penalty for pain immunity when needed.