I would like to see detailed and unique NPCs and various interactivity between them. You can pickpocket them, rob them, invite them to join your gang. Befriend and earn their trust or bring them to an alleyway and steal their house key and loot their goods. I feel like these mechanics would fit in with Cyberpunk 2077, a game where evil and danger lurks everywhere. You can break into their houses like in Skyrim and loot their goods. Also these interactions can happen to you if you're not careful. The atmosphere of Vampire: The Masquerade where you could break into a hospital, sneak past security guards, hack computer terminals to open up locked rooms, etc. A game with NPCs that are lively and have unique schedules and many interactions with the world and your character. They are located at different places during day and night. They each have names, jobs and maybe you can scan them for more personal info like age, gender and income, etc. I believe this was done in Watch Dogs. Also different interactions for example you can pickpocket someone's car keys. Or you can beat them up and get it that way. Also extortion like threatening a vendor to give you better deals, or steal the goods at night. All of these interactions can be skills that you develop to further enhance more interactions and make the skill fail less. Of course all interactions doesn't have to be bad it can be good things too like chatting and getting to know someone or fulfilling a request. For example you do a quest for a hacker and he is now an acquaintance, so he can help you hack the world's most secure networks and this was some random guy you met on the street out of the many NPCs that each have skills that can help you on your journey.