Really, I think at the start, during the starting missions, the only difference between the roles would be where you start the game, where your default safe house is...
Though it would be kinda fun to get cameos of the NPC's filling out the other roles in early mission cutscenes before you actually meet them.... like you see them buying eggs and some shit...
Hell maybe have the NPC's whose role you have taken over be shown to be killed during the opening sequence...
Oooh! This would be cool. Sort-of like in the trailer where we see Swaggy's body.
Still hoping safe houses are few or non-existent. It's not GTA. Although I did like the Vampire:Bloodlines apartments. Very atmospheric.
I'd also like to see story bits for different Roles that featured utterly different kinds of "safe"houses, if we have to have them, with different improve-your-base missions.