Welcome to the Forums,
MGTenshi!
Sounds like the new OS is blocking permissions / not configured properly for the game.
1.) Am I to understand that the game was running fine before you updated to Windows 10?
2.) Is this the same system (hardware)? Can you please provide more info: system specs, where you got the game, which version you're running, etc?
3.) Using any mods, or have you ever used any? If so, uninstall (do not simply disable) all mods and any mod manager you used to install them.
4.) Please ensure the game is not installed anywhere under Program Files or Program Files(x86). (This may require you to relocate your entire Steam / Origin / Galaxy directory. Direct download GOG installations can simply be dragged and dropped into a new location.) After doing this, set
witcher3.exe to "Run as administrator".
5.) Ensure the driver you're using is an official
reference driver, and ensure that the version is compatible with Windows 10. Install the driver itself using the CLEAN installation option.
6.) After ensuring all of the above is in order, run another verify / repair.