I dunno... Fifty-plus years means a lot of people will have slipped by, burned out, or went bad. Morgan is probably gone, killed in the blast that closed the Fourth Corporate War. Santiago's descendants are probably roving around, but I doubt Santiago is with them anywhere outside of story time. Spider might be a grandmother as she always had a knack for survival, knowing when to lay low and getting very good at covering her tracks. Depending on how the post-CP2020 storyline merges into CP2077, she might even have gone legit. She was one of the more stable voices of reason among Edgerunners and could have found a way. She is apparently mentioned in 203X, but like you, I'm not fond of that setting and didn't pay it much attention.