Yes and no. What some others has said, fluid combat say headshots, should drop targets fast. That damage in numbers is about something absurd is kinda moot. It's what happen in practical game play terms. Built also aren't equal, even max level Annihilation doesn't drop enemies on normal with body shots with legendary shotguns, and then there's perhaps just two legendary shotguns in game. I think you can get the picture that in close quarters combat also mobility perks are already important, especially if player hasn't found those shotguns.
Something I thought. We have all sorts of equipment available in game. So on harder difficulties more enemies could wear helmets. Then some boss enemies, could have second heart, so they would come back, subdermal armor on selected enemies could more common. These could be also made optional difficulty challenges, like Very Hard + Cybered up enemies.
I also concur what Yota71 wrote above. Melee builds and bullet sponges are very difficult combination and is also a matter of skill progression. Situation where player can't reliably melee but last one, or last two enemies still standing, getting exp to level up Brawling and Athletics could become very difficult, limiting practical build options for players.
But more optional challenges for difficulties and since those could also be tied to achievements I think they might turn out even be something quite popular.
There's actually something very clever problem solving in game already and I think CDPR could make this work but people must ask for these things.