The only difficulty spike I have, is with the "beat on the brat" side mission chain involving fistfights.
Im now lvl 34ish, with 20 reflex and 16 body amd 900+ armor and I am knocked down in two or less hits by "moderate" difficulty opponent.
What is even more troubling, is that dodging simply doesn't work against these opponents. They will auto-track and hit regardless if you dodge or not (and I know, because I have kerenzikov and succesful dodge means slow-motion. Then in slow-motion I see the opponent swivel and track me with their fist and knock me on my ass.)
This means that ONLY parries can work against these enemies, and did I mention that my hits do like 0.5% per hit? They KO me in two hits? And blocking does nothing?
There is something seriously wrong with these fistfight missions, judging how laughably easy everything else is.