Remember when NG+ came as final free DLC for Witcher 3? Maybe CDPR could combine NG+ for Cyberpunk with this new mechanic: Yes, you are overpowered, but if you use it too much, you lose control and MAxtac hunts you – like the vampire hunters in VAmoire Masquerade Bloodlines, when you broke the Masquerade too much.
Now that they've moved forward from only fixing technicalities, they could well consider a new.... let's say, difficulty setup that does indeed include humanity cost for cyberware. And in addition increases the accuracy and recoil penalties for low skill in combat (so that the curve of V learning to fight is more visible and feelable to the player in more ways than just seeing damage and armor numbers going up; that low skills actually feel low skills). And while at it, why not make skill checks rolls that work close to like they do in 2020 (i.e. skill =/> difficulty -> success -- skill < difficulty -> skill+roll d10 = attempt at = or > difficulty). There's obviously more to it than just that, but the general idea should be clear.
Kind of a "HC mode". Maybe not even tie it to difficulty, but let it be chosen (or not chosen) at the start of the game along with any difficulty setup to enhance it if the player so wishes.