The issue seems confirmed with "our" cards, but just want to add to the topic... i5 4690k, 16GB Ram, Sapphire R9 285 Dual-X (Non OC). Random, but pretty much inevitable crashes while in combat. I've tried all possible combinations, including overclocking CPU/GPU, running it stock. Switching between windowed/full screen, from low to high preset. Everything to no avail. :,(
To be honest, the issue is a bit unsettling. Especially, since I've come across another exclusive to 285's problem, in Game of Thrones by Tell Tales. The issue of really thick, black outlines of everything (characters etc.), have been known by both developers and AMD for a long time now, yet still stays unresolved. The only solution was to roll back drivers, to the ones before Omega. Not really a solution If you ask me.
Not really sure how much help we can expect from CDPR, since it only affects one GPU (as far as I know). I'd expect more coming from the AMD... and we all know how often they come up with new drivers.